Mary Jane Napurrula Spencer was born in 1996 in Alice Springs Hospital, the closest hospital to Yuendumu, a remote Aboriginal community located 290 km north-west of Alice Springs in the NT of Australia. She grew up in Yuendumu and attended the local school. She is married and has two children. She currently lives in Hermannsburg, an Aboriginal community 131 km southwest of Alice Springs.
When Mary Jane visits family in Yuendumu she often paints with Warlukurlangu Artists Aboriginal Corporation, an Aboriginal owned and governed art centre. She paints sculptural objects, a new line introduced by Warlukurlangu for novice artists to develop their design and brush stroke skills.